The two sides have met many times at Prenton Park over the years, and here we look back at one of those previous trips.
It’s from October 21, 2014, when Paul Cox took his Stags side to Tranmere for what was also a League Two fixture, the game ending in a 0-0 draw.
See if you can remember any Stags players from that night’s action.
1. Tranmere v Mansfield - Oct 2014
Mansfield Town's new loan signing Daniel Carr made his debut at Prenton Park as a sub.
2. Tranmere v Mansfield - Oct 2014
Alex Fisher is tackled by Tranmere's Marc Laird.
3. Tranmere v Mansfield - Oct 2014
Alex Fisher takes on the Tranmere defence.
4. Tranmere v Mansfield - Oct 2014
Jamie McGuire shoots narrowly wide for Mansfield.