Two lanes of the southbound side are reportedly still closed after the crash between a lorry and a car this afternoon.
Firefighters from Nottingham Road, Long Eaton and Castle Donington attended.
A fire and rescue spokesman said: "Two casualties were trapped by their injuries, hydraulic cutting gear was used for extrication and the vehicles were made safe."
Large fire in Kirkby may have been a 'deliberate or a careless act'
Creswell properties evacuated as fire crews tackle field blaze
Inclusive cricket club in Mansfield is bowled over by donation
Appeal for help after man attacked with champagne bottle outside Eastwood pub
Memorial bench to honour two much-loved characters in Stanton Hill
Highways England said: "Long delays on approach. Please allow extra time or consider alternative routes this afternoon.