The 50-year-old was driving on the A631 Somerby when his Ford Fiesta van collided with a lorry.
A Lincolnshire Police spokesman said: “The driver was seriously injured and taken to hospital for treatment where he remains this morning.
“The lorry driver was not injured.”
Both vehicles were travelling towards Gainsborough and the road was closed at Corringham for a number of hours following the collision.
Police are appealing for anybody who witnessed the incident, which took place just after 5pm.
Anyone with information about the accident should contact the Lincolnshire Police Collision Witness Hotline on 01522 558855 quoting incident 347 of September 24 2015.