The Portuguese eaterie will open a restaurant in the town in September.
A spokesman for the popular franchise – which specialises in chicken dishes – said: “We’re thrilled to reveal this news.”
The announcement comes after Chesterfield man Chris Cordin, 22, set up an online petition calling for the national chain to move to the town.
He said: “I started this petition because I always had to travel to Sheffield to get a Nando’s – they have three or four of them there already.
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“I’m very happy it’s coming to Chesterfield.
“I’m a big chicken lover and glad I won’t have to go far to get my fix now!”
Our online story exclusively revealing the news on Monday was viewed by thousands of people.
And the article has been shared almost 2,000 times on social networking sites Facebook and Twitter.
On Facebook, Laura Whitworth said: “I’m so excited!”
Michelle Hoole said: “It’s about time we had a Nando’s!”
Jax Palfreyman added: “Wahey! Now all we need is a Starbucks.”
On Twitter, @amesrussy said: “This is the best news I’ve heard in ages!”
@bethmcinnes_ said: “Looks like the new @NandosUK in Chesterfield will have to be the size of a small stadium to meet its demand! Long overdue!”
@kenhuckle said: “I’m quite a fan of @NandosUK so naturally delighted that they have confirmed they will open a restaurant in Chesterfield.”
@leeeonix said: “Nothing can hide my excitment for Nando’s coming to Chesterfield.”
@RaveCeleste added: “Chesterfield just got a little bit better!”
However, not everyone was happy.
On Facebook, Sally Lee said: “How about supporting local independant restaurants instead of ‘could be anywhere’ eating places?”
And on Twitter, bbbbwebb said: “Couldn’t be less bothered about a Nando’s in Chesterfield.”
The location of the restaurant is yet to be confirmed.
The Nando’s spokesman added that more details will be released soon.
Founded in 1987, Nando’s operates about 1,000 outlets in 24 countries.