More than 120 jobs will be created at a new car parts distribution centre at the Markham Vale business site.
The facility is being built by Leeds firm Andrew Page with construction work expected to be finished by August.
Mark Roberts, managing director of Andrew Page, said: “Markham Vale has excellent communication links, immediate access to the M1 motorway and is the ideal location for our national distribution facility.
“We are delighted to bring 120 jobs to Derbyshire.”
The county council is leading a regeneration project to attract companies to the £62m business park, situated on the 200-acre former coalfield site, near the M1.
Regeneration chief Coun Kevin Parkinson said the news was “fantastic”.